Norsk nyreregister

Forskning

Det er i løpet av 2016 og frem til september 2017 publisert 52 vitenskapelige artikler i internasjonale tidskrift (se publikasjonsliste under) og 8 kandidater har forsvart sine doktorgrader som til dels er basert på data fra NNR i denne perioden.

I 2015 publiserte den europeiske legemiddelmyndigheten (EMA) en varsel om at mannlige transplanterte pasienter som bruker det mye brukte immundempende legemidlet mykofenolat (CellCept®, Myfortic®) måtte bruke kondom ved seksuell aktivitet pga. en potensiell risiko for foster. NNR data er blitt koblet med data fra Medisinsk fødselsregister og det er ikke noen tegn til en slik fosterskadelig effekt av at mannlige transplanterte bruker mykofenolat. Disse dataene fikk stor oppmerksomhet ved den Europeiske transplantasjonskongressen i Barcelona, 24-27. september 2017. Dataene er publisert i det annerkjente tidskriftet Transplantation [Midtvedt K et al. Transplantation 2017; 101: e214-e217].

Tabell: Fødselsutkom i gruppen der far har vært eksponert for mykofenolat sammenlignet med gruppen som ikke hadde vært eksponert for mykofenolat.

 

MPA+

N=155

MPA-

N=195

p-value

Acute caesarean section

16 (10.3%)

24 (12.3%)

0.39

Normal placenta

121 (78.1%)

118 (60.5%)

0.32

Child weight (g)

3,381 ±681

3,429 ±714

0.53

Gestational age (wk)

38.9 ±2.5

39.1 ±2.7

0.30

Child length (cm)

49.6 ±3.2

49.9 ±3.0

0.32

Child head circumference (cm)

34.7 ±2.1

35.1 ±2.1

0.12

APGAR score after 1 minute

8.6 ±1.5

8.6 ±1.5

0.97

APGAR score after 5 minutes

9.3 ±1.3

9.3 ±1.4

0.41

Stillborn

1 (0.6%)

4 (2.1%)

0.12

Born alive, dead within 24 h

0 (0.0%)

1 (0.5%)

0.32

Congenital malformations

6 (3.9%)

5 (2.6%)

0.49

Respiratory distress syndrome

4 (2.6%)

2 (1.0%)

0.40

Neural tube defects

0 (0.0%)

0 (0.0%)

1.00

Icterus

11 (7.1%)

12 (6.2%)

0.33

Hip dysplasia

1 (0.6%)

1 (0.5%)

1.00

Publikasjonsliste

  1. Dahle DO, Åsberg A, Hartmann A, Holdaas H, Bachtler M, Jenssen TG, Dionisi M, Pasch A. Serum calcification propensity is a strong and independent determinant of cardiac and all-cause mortality in kidney transplant recipients. Am J Transplant 2016; 16(1): 204-212.
  2. Eide IA, Halden TAS, Hartmann A, Åsberg A, Dahle DO, Reisæter AV, Jenssen TG. Mortality risk in posttransplantation diabetes mellitus based on glucose and HbA1c diagnostic criteria. Transpl Int 2016; 29(5): 568-578.
  3. Eide IA, Dahle DO, Svensson M, Hartmann A, Bjerve KS, Christensen JH, Schmidt EB, Lauritsen ME, Lund K, Åsberg A, Jenssen T. Plasma levels of marine n-3 fatty acids and cardiovascular risk markers in renal transplant recipients. Eur J Clin Nutr 2016; 70(7): 824-830.
  4. Størset E, Åsberg A, Hartmann A, Reisæter AV, Holdaas H, Skauby M, Bergan S, Midtvedt M. Low-target tacrolimus in de novo standard risk renal transplant recipients - a single-center experience. Nephrology 2016; 21(10): 821-827.
  5. Smedbråten J, Mjøen G, Hartmann A, Åsberg A, Rollag H, Mollnes TE, Sandvik L, Fagerland MW, Thiel S, Sagedal S. Low level of MAp44, an inhibitor of the lectin complement pathway, and long-term graft and patient survival; a cohort study of 382 kidney recipients. BMC Nephrology 2016; 17(1): 148.
  6. Koopman JJE, Kramer A, van Heemst D, Åsberg A, Beuscart JB, Buturović-Ponikvar J, Collart F, Couchoud CG, Finne P, Heaf JG, Massy ZA, De Meester JMJ, Pálsson R, Steenkamp R, Traynor JP, Jager KJ, Putter H. Measuring senescence rates of patients with end-stage renal disease while accounting for population heterogeneity: an analysis of data from the ERA-EDTA Registry. Annals of Epidemiology 2016; 26(11): 773-779.
  7. Smedbråten J, Sagedal S, Åsberg A, Hartmann A, Rollag H, Mjøen G, Fagerland MW, Hansen SWK, Mollnes TE, Thiel S. Collectin Liver 1 and Collectin Kidney 1 of the lectin complement pathway are associated with mortality after kidney transplantation. Am J Transplant 2017; 17(1): 265-271.
  8. Pippias M, Kramer A, Noordzij M, Alonso de la Torre R, Ambühl PM, Aparicio MMI, Arribas Monzón F, Åsberg A, Bonthuis M, Bouzas Caamaño E, Bubic I, Caskey FJ, Castro de la Nuez P, Cernevskis H, de los Ángeles GBM, des Grottes J-M, Fernández GR, Ferrer-Alamar M, Finne P, Garneata L, Golan E, Heaf JG, Hemmelder MH, Idrizi A, Ioannou K, Jarraya F, Kantaria N, Kolesnyk M, Kramar R, Lassalle M, Lezaic VV, Lopot F, Macario F, Magaz A, Martín de Francisco AL, Martín EE, Martínez Castelao A, Metcalfe W, Moreno Alia I, Nordio M, Ots-Rosenberg M, Palsson R, Ratkovic M, Resic H, Rutkowski B, Santiuste de Pablos C, Seyahi N, Slon Roblero MF, Spustova V, Stas Koenraad JF, Stendahl Mara E, Stojceva-Taneva O, Vazelov E, Ziginskiene E, Massy Z, Jager KJ, and Stel Vianda S. The European Renal Association–European Dialysis and Transplant Association (ERA-EDTA) Registry Annual Report 2014: A summary. Clin Kidney J 2017; 10(2): 154-169.
  9. Eide IA, Halden TAS, Hartmann A, Åsberg A, Dahle DO, Jenssen TG. Associations between posttransplantation diabetes mellitus and renal graft survival. Transplantation 2017; 101(6): 1282-1289.
  10. Midtvedt K, Bergan S, Reisæter AV, Vikse BE, Åsberg A. Exposure to mycophenolate and fatherhood. Transplantation 2017; 101(7); e214-e217.
  11. Lindahl P, Horneland R, Nordheim E, Hartmann A, Aandahl EM, Grzyb K, Haugaa H, Kjøsen G, Åsberg A, Jenssen T. Outcomes in Pancreas Transplantation Alone versus Simultaneous Pancreas and Kidney Transplantation with Exocrine Drainage through a Duodenoduodenostomy. Am J Transplant 2017, doi: 10.1111/ajt.14420 [ePUB].
  12. Dupont L, Eide IA, Hartmann A, Christensen JH, Åsberg A, Jenssen T, Krarupm H, Svensson M. Haptoglobin 2-2 genotype, patient and graft survival in renal transplant recipients. Progress in Transplantation, in press.
  13. Gagnum V, Stene LC, Leivestad T, Joner G, Skrivarhaug T. Long-term Mortality and End-Stage Renal Disease in a Type 1 Diabetes Population Diagnosed at Age 15-29 Years in Norway. Diabetes Care. 2017; 40(1): 38-45
  14. Dahle DO, Grotmol T, Leivestad T, Hartmann A, Midtvedt K, Reisæter AV, Mjøen G, Pihlstrøm HK, Næss H, Holdaas H. Association Between Pretransplant Cancer and Survival in Kidney Transplant Recipients. Transplantation. 2017; 101(10): 2599-2605
  15. Heldal K, Hartmann A, Lønning K, Leivestad T, Reisæter AV, Line PD, Holdaas H, Midtvedt K. Should patients older than 65 years be offered a second kidney transplant? BMC Nephrol. 2017; 18(1): 13
  16. Vidal E, van Stralen KJ, Chesnaye NC, Bonthuis M, Holmberg C, Zurowska A, Trivelli A, Da Silva JEE, Herthelius M, Adams B, Bjerre A, Jankauskiene A, Miteva P, Emirova K, Bayazit AK, Mache CJ, Sánchez-Moreno A, Harambat J, Groothoff JW, Jager KJ, Schaefer F, Verrina E; ESPN/ERA-EDTA Registry. Infants Requiring Maintenance Dialysis: Outcomes of Hemodialysis and Peritoneal Dialysis. Am J Kidney Dis. 2017; 69(5): 617-625
  17. Lønning K, Midtvedt K, Bernklev T, Brunborg C, Andersen MH, von der Lippe N, Reisaeter AV, Line PD, Hartmann A, Heldal K. Changes in health related quality of life in older candidates waiting for kidney transplantation. Nephrology (Carlton). 2017. doi: 10.1111/nep.13117. [ePUB]
  18. Koefoed-Nielsen P, Weinreich I, Bengtsson M, Lauronen J, Naper C, Gäbel M, Sørensen SS, Wennberg L, Reisaeter AV, Møller BK; Nordic Kidney group and the Tissue Typing group in Scandiatransplant. Scandiatransplant acceptable mismatch program (STAMP) a bridge to transplanting highly immunized patients. HLA. 2017; 90(1): 17-24
  19. Majak GB, Reisæter AV, Zucknick M, Lorentzen B, Vangen S, Henriksen T, Michelsen TM. Preeclampsia in kidney transplanted women; Outcomes and a simple prognostic risk score system. PLoS One. 2017; 12(3): e0173420
  20. van den Brand JAJG, Pippias M, Stel VS, Caskey FJ, Collart F, Finne P, Heaf J, Jais JP, Kramar R, Massy ZA, De Meester J, Traynor JP, Reisæter AV, Wetzels JFM, Jager KJ. Lifetime risk of renal replacement therapy in Europe: a population-based study using data from the ERA-EDTA Registry. Nephrol Dial Transplant. 2017; 32(2): 348-355
  21. Svarstad E, Leh S, Skrunes R, Kampevold Larsen K, Eikrem Ø, Tøndel C. Bedside  Stereomicroscopy of Fabry Kidney Biopsies: An Easily Available Method for Diagnosis and Assessment of Sphingolipid Deposits. Nephron. 2017. doi: 10.1159/000479751. [ePUB]
  22. Skrunes R, Tøndel C, Leh S, Larsen KK, Houge G, Davidsen ES, Hollak C, van Kuilenburg ABP, Vaz FM, Svarstad E. Long-Term Dose-Dependent Agalsidase Effects on Kidney Histology in Fabry Disease. Clin J Am Soc Nephrol. 2017; 12(9): 1470-1479
  23. Skrunes R, Svarstad E, Kampevold Larsen K, Leh S, Tøndel C. Reaccumulation of  globotriaosylceramide in podocytes after agalsidase dose reduction in young Fabry patients. Nephrol Dial Transplant. 2017; 32(5): 807-813
  24. Norby GE, Mjøen G, Bjørneklett R, Vikse BE, Holdaas H, Svarstad E, Aasarød K.  Outcome in biopsy-proven Lupus nephritis: Evaluation of biopsies from the Norwegian Kidney Biopsy Registry. Lupus. 2017; 26(8): 881-885
  25. van den Brand JAJG, Pippias M, Stel VS, Caskey FJ, Collart F, Finne P, Heaf J, Jais JP, Kramar R, Massy ZA, De Meester J, Traynor JP, Reisæter AV, Wetzels JFM,  Jager KJ. Lifetime risk of renal replacement therapy in Europe: a population-based study using data from the ERA-EDTA Registry. Nephrol Dial Transplant. 2017; 32(2): 348-355
  26. Chesnaye NC, Schaefer F, Bonthuis M, Holman R, Baiko S, Baskın E, Bjerre A, Cloarec S, Cornelissen EAM, Espinosa L, Heaf J, Stone R, Shtiza D, Zagozdzon I, Harambat J, Jager KJ, Groothoff JW, van Stralen KJ; ESPN/ERA-EDTA Registry Committee. Mortality risk disparities in children receiving chronic renal replacement therapy for the treatment of end-stage renal disease across Europe: an ESPN-ERA/EDTA registry analysis. Lancet. 2017; 389(10084): 2128-2137
  27. Lønning K, Midtvedt K, Leivestad T, Reisæter AV, Line PD, Hartmann A, Heldal K. Are Octogenarians With End-Stage Renal Disease Candidates for Renal Transplantation? Transplantation. 2016; 100(12): 2705-2709.
  28. Mekahli D, van Stralen KJ, Bonthuis M, Jager KJ, Balat A, Benetti E, Godefroid N, Edvardsson VO, Heaf JG, Jankauskiene A, Kerecuk L, Marinova S, Puteo F, Seeman T, Zurowska A, Pirenne J, Schaefer F, Groothoff JW; ESPN/ERA-EDTA Registry. Kidney Versus Combined Kidney and Liver Transplantation in Young People With Autosomal Recessive Polycystic Kidney Disease: Data From the European Society for Pediatric Nephrology/European Renal Association-European Dialysis and Transplant  (ESPN/ERA-EDTA) Registry. Am J Kidney Dis. 2016; 68(5): 782-788
  29. Lindahl JP, Massey RJ, Hartmann A, Aakhus S, Endresen K, Günther A, Midtvedt K, Holdaas H, Leivestad T, Horneland R, Øyen O, Jenssen T. Cardiac Assessment of Patients With Type 1 Diabetes Median 10 Years After Successful Simultaneous Pancreas and Kidney Transplantation Compared With Living Donor Kidney Transplantation. Transplantation. 2017; 101(6): 1261-1267
  30. Knoop T, Vikse BE, Mwakimonga A, Leh S, Bjørneklett R. Long-term outcome in 145 patients with assumed benign IgA nephropathy. Nephrol Dial Transplant. 2017. doi: 10.1093/ndt/gfx242 [ePUB]
  31. Hogan J, Couchoud C, Bonthuis M, Groothoff JW, Jager KJ, Schaefer F, Van Stralen KJ; ESPN/ERA-EDTA Registry. Gender Disparities in Access to Pediatric Renal Transplantation in Europe: Data From the ESPN/ERA-EDTA Registry. Am J Transplant. 2016; 16(7): 2097-105
  32. Lindahl JP, Hartmann A, Aakhus S, Endresen K, Midtvedt K, Holdaas H, Leivestad T, Horneland R, Øyen O, Jenssen T. Long-term cardiovascular outcomes in type 1 diabetic patients after simultaneous pancreas and kidney transplantation compared with living donor kidney transplantation. Diabetologia. 2016; 59(4): 844-52
  33. Tjaden LA, Noordzij M, van Stralen KJ, Kuehni CE, Raes A, Cornelissen EA, O'Brien C, Papachristou F, Schaefer F, Groothoff JW, Jager KJ; ESPN/ERA-EDTA Registry Study Group. Racial Disparities in Access to and Outcomes of Kidney Transplantation in Children, Adolescents, and Young Adults: Results From the ESPN/ERA-EDTA (European Society of Pediatric Nephrology/European Renal Association-European Dialysis and Transplant Association) Registry. Am J Kidney Dis. 2016; 67(2): 293-301
  34. Krischock LA, van Stralen KJ, Verrina E, Tizard EJ, Bonthuis M, Reusz G, Hussain FK, Jankauskiene A, Novljan G, Spasojević-Dimitrijeva B, Podracka L, Zaller V, Jager KJ, Schaefer F; ESPN/ERA-EDTA Registry. Anemia in children following renal transplantation-results from the ESPN/ERA-EDTA Registry. Pediatr Nephrol. 2016; 31(2): 325-33
  35. Pippias M, Jager KJ, Kramer A, Leivestad T, Sánchez MB, Caskey FJ, Collart F, Couchoud C, Dekker FW, Finne P, Fouque D, Heaf JG, Hemmelder MH, Kramar R, De Meester J, Noordzij M, Palsson R, Pascual J, Zurriaga O, Wanner C, Stel VS. The changing trends and outcomes in renal replacement therapy: data from the ERA-EDTA Registry. Nephrol Dial Transplant. 2016; 31(5): 831-41
  36. Lofaro D, Jager KJ, Abu-Hanna A, Groothoff JW, Arikoski P, Hoecker B, Roussey-Kesler G, Spasojević B, Verrina E, Schaefer F, van Stralen KJ; ESPN/ERA-EDTA Registry. Identification of subgroups by risk of graft failure after paediatric renal transplantation: application of survival tree models on the ESPN/ERA-EDTA Registry. Nephrol Dial Transplant. 2016; 31(2): 317-24
  37. Skrunes R, Svarstad E, Reisæter AV, Marti HP, Vikse BE. End Stage Renal Disease Predicts Increased Risk of Death in First Degree Relatives in the Norwegian Population. PLoS One. 2016; 11(11): e0165026
  38. Mjoen G, Reisaeter AV, Dahle DO. HLA Mismatch and Allograft Survival. Transplantation. 2016; 100(9): e52
  39. Majak GB, Sandven I, Lorentzen B, Vangen S, Reisaeter AV, Henriksen T, Michelsen TM. Pregnancy outcomes following maternal kidney transplantation: a national cohort study. Acta Obstet Gynecol Scand. 2016; 95(10): 1153-61
  40. Mjøen G, Reisaeter A, Hallan S, Line PD, Hartmann A, Midtvedt K, Foss A, Dahle DO, Holdaas H. Overall and cardiovascular mortality in Norwegian kidney donors compared to the background population. Nephrol Dial Transplant. 2016; 31(1): 170
  41. Pippias M, Stel VS, Aresté-Fosalba N, Couchoud C, Fernandez-Fresnedo G, Finne P, Heaf JG, Hoitsma A, De Meester J, Pálsson R, Ravani P, Segelmark M, Traynor JP, Reisæter AV, Caskey FJ, Jager KJ. Long-term Kidney Transplant Outcomes in Primary Glomerulonephritis: Analysis From the ERA-EDTA Registry. Transplantation. 2016; 100(9): 1955-62
  42. Eide IA, Jenssen T, Hartmann A, Diep LM, Dahle DO, Reisæter AV, Bjerve KS, Christensen JH, Schmidt EB, Svensson M. Plasma levels of marine n-3 polyunsaturated fatty acids and renal allograft survival. Nephrol Dial Transplant. 2016; 31(1): 160-7
  43. von der Lippe N, Waldum-Grevbo B, Varberg Reisæter A, Os I. Is HRQOL in dialysis associated with patient survival or graft function after kidney transplantation? BMC Nephrol. 2016; 17: 94
  44. Ruggajo P, Skrunes R, Svarstad E, Skjærven R, Reisæther AV, Vikse BE. Familial Factors, Low Birth Weight, and Development of ESRD: A Nationwide Registry Study.  Am J Kidney Dis. 2016; 67(4): 601-8
  45. Ruggajo P, Svarstad E, Leh S, Marti HP, Reisæther AV, Vikse BE. Low Birth Weight and Risk of Progression to End Stage Renal Disease in IgA Nephropathy--A Retrospective Registry-Based Cohort Study. PLoS One. 2016; 11(4): e0153819
  46. Bjørneklett R, Sriskandarajah S, Bostad L. Prognostic Value of Histologic Classification of ANCA-Associated Glomerulonephritis. Clin J Am Soc Nephrol. 2016; 11(12): 2159-2167
  47. Diciolla M, Binetti G, Di Noia T, Pesce F, Schena FP, Vågane AM, Bjørneklett R, Suzuki H, Tomino Y, Naso D. Patient classification and outcome prediction in IgA nephropathy. Comput Biol Med. 2015; 66: 278-86
  48. Pesce F, Diciolla M, Binetti G, Naso D, Ostuni VC, Di Noia T, Vågane AM, Bjørneklett R, Suzuki H, Tomino Y, Di Sciascio E, Schena FP. Clinical decision support system for end-stage kidney disease risk estimation in IgA nephropathy patients. Nephrol Dial Transplant. 2016; 31(1): 80-6
  49. Hölttä T, Bonthuis M, Van Stralen KJ, Bjerre A, Topaloglu R, Ozaltin F, Holmberg C, Harambat J, Jager KJ, Schaefer F, Groothoff JW. Timing of renal replacement therapy does not influence survival and growth in children with congenital nephrotic syndrome caused by mutations in NPHS1: data from the ESPN/ERA-EDTA Registry. Pediatr Nephrol. 2016; 31(12): 2317-2325
  50. Hogan J, Couchoud C, Bonthuis M, Groothoff JW, Jager KJ, Schaefer F, Van Stralen KJ; ESPN/ERA-EDTA Registry. Gender Disparities in Access to Pediatric Renal Transplantation in Europe: Data From the ESPN/ERA-EDTA Registry. Am J Transplant. 2016; 16(7): 2097-105
  51. Kramer A, Pippias M, Stel VS, Bonthuis M, Abad Diez JM, Afentakis N, Alonso de la Torre R, Ambuhl P, Bikbov B, Bouzas Caamaño E, Bubic I, Buturovic-Ponikvar J,  Caskey FJ, Castro de la Nuez P, Cernevskis H, Collart F, Comas Farnés J, Garcia Bazaga Mde L, De Meester J, Ferrer Alamar M, Finne P, Garneata L, Golan E, G Heaf J, Hemmelder M, Ioannou K, Kantaria N, Kolesnyk M, Kramar R, Lassalle M, Lezaic V, Lopot F, Macário F, Magaz A, Martín-Escobar E, Metcalfe W, Ots-Rosenberg M, Palsson R, Piñera Celestino C, Resić H, Rutkowski B, Santiuste de Pablos C, Spustová V, Stendahl M, Strakosha A, Süleymanlar G, Torres Guinea M, Varberg Reisæter A, Vazelov E, Ziginskiene E, Massy ZA, Wanner C, Jager KJ, Noordzij M. Renal replacement therapy in Europe: a summary of the 2013 ERA-EDTA Registry Annual Report with a focus on diabetes mellitus. Clin Kidney J. 2016; 9(3): 457-69
  52. van de Luijtgaarden MW, Jager KJ, Segelmark M, Pascual J, Collart F, Hemke AC, Remón C, Metcalfe W, Miguel A, Kramar R, Aasarød K, Abu Hanna A, Krediet RT, Schön S, Ravani P, Caskey FJ, Couchoud C, Palsson R, Wanner C, Finne P, Noordzij  M. Trends in dialysis modality choice and related patient survival in the ERA-EDTA Registry over a 20-year period. Nephrol Dial Transplant. 2016; 31(1): 120-8